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M. Faisal, Ibrahim
- Short-term Treatment with Atorvastatin Selectively Decreases Lymphocyte Count
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Authors
Affiliations
1 College of Pharmacy, University of Mosul, Mosul,, IQ
2 College of Medicine, University of Mosul, Mosul,, IQ
1 College of Pharmacy, University of Mosul, Mosul,, IQ
2 College of Medicine, University of Mosul, Mosul,, IQ
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 689-694Abstract
Statins are a chemically related group used as lipid-lowering agents, studies confirmed that statins have additional pleiotropic, cholesterol independent, effects mediated by inhibition of isoprenoid synthesis with subsequent inhibition of the downstream signaling molecules like Rho, Rac, and Ras. However, different statin members might have a distinctive effect on the immune system; thereby having different peripheral and cardiovascular actions, such extra-hepatic effects impose the preferences of one statin over another. The present study aimed to identify the role of the short-term utilization of atorvastatin on leukocyte concentration as a representative in vivo marker for immunomodulation. Two widely used statin agents were included in the study- the lipophilic (atorvastatin) versus the hydrophilic (rosuvastatin) for comparison. Blood samples were withdrawn from the two statin groups, before and after therapy, and an automated differential white blood cell count was performed to determine the difference between the studied samples. The results showed that short-term use of atorvastatin, but not rosuvastatin, was associated with a selective reduction of lymphocyte count (p<0.0001). The study concluded that lymphocyte levels were reduced significantly after short-term use of atorvastatin; an effect which might need to be considered in certain immunological disease associated with cardiac ones.
Keywords
Lymphocyte, Atorvastatin, Rosuvastatin, Pleiotropic, Anti-inflammatory.
References
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- Fluvoxamine Suppressed Oxidative Stress Associated with Tissue Erosion
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Authors
Affiliations
1 Ninawa Health Directorate, Mosul,, IQ
2 College of Medicine, University of Mosul,, IQ
3 College of Veterinary Medicine University of Mosul,, IQ
4 College of Pharmacy, University of Mosul, Mosul,, IQ
1 Ninawa Health Directorate, Mosul,, IQ
2 College of Medicine, University of Mosul,, IQ
3 College of Veterinary Medicine University of Mosul,, IQ
4 College of Pharmacy, University of Mosul, Mosul,, IQ
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 819-824Abstract
Centrally-acting drugs have been increasingly used for gastrointestinal diseases, such as opioids used for diarrhea and phenothiazine as antiemetic agents. Recent reports focused on the identification of the efficacy of these drugs in peptic ulcer protection; by tackling the oxidative stress associated with the inflammatory reaction of ulceration. The present study aimed to identify the differences between fluoxetine versus fluvoxamine in terms of antioxidant activity. To do so, an animal model of stress-induced ulcer was utilized by exposing rats to high doses of indomethacin and these rats were sub-classified into four groups (control, fluoxetine, fluvoxamine, and misoprostol) for comparison. Blood samples were collected from the studied groups and analyzed by measuring plasma levels of total antioxidant and malondialdehyde (MDA). The results confirmed that fluvoxamine possesses an antioxidant activity that is comparable to misoprostol and significantly higher than that of fluoxetine effects; the latter showed a non-significant effect in ordinary doses. In conclusion, these findings might provide a clue for future directions for the discovery of new antiulcer agents through structural modification of the newly introduced antidepressant agents in clinical use.Keywords
Fluvoxamine, Fluoxetine, Indomethacin, Antioxidant, Malondialdehyde.References
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